"Something's Gotten Hold of My Heart" is a song written by Roger Greenaway and Roger Cook.

Originally recorded by David and Jonathan, and then Gene Pitney in 1967, the latter's version of the song reached No. 5 on the UK Singles Chart in December 1967, but failed to chart in the United States. The song was subsequently covered by a number of other acts including Cilla Black, Allison Durbin (dubbed "Australia's Queen of Pop" in the 1960s) on her 1968 album I Have Loved Me a Man, Terry Reid, and Nick Cave and the Bad Seeds on their 1986 album of covers Kicking Against the Pricks. It was sung in French by Herbert Léonard in 1968 with the title "Quelque chose tient mon cœur" and in Italian by Pitney himself with the title "Uomo, non sai" ("Man, you don't know").

It achieved its greatest success in 1988 when Some Bizzare UK Record label released a cover version by Marc Almond. Originally recorded by Almond alone for his 1988 album The Stars We Are, the single version reunited it with its best-known singer, Gene Pitney. Their version became a number one single in the UK for four weeks in January 1989. The music video for this version was filmed on-location in Las Vegas.